Medical Treatment with Anti-Thyroid Drugs (Methimazole; Tapazole ®)
   
  Advantages
 
  • Relatively inexpensive compared with radiotherapy or surgery (in the short-term)
  • No hospitalization required
  • No permanent hypothyroidism
  • No hypoparathyroidism (hypocalcemia)
   
  Disadvantages
 
  • The price of methimazole has gone up dramatically in the last few years, making the total cost of long-term administration equivalent to that of definitive treatments.
  • Medication must be given daily (usually twice daily). Damage to your relationship with your cat is possible due to the difficulties of pilling your cat several times daily.
  • During long-term treatment, relapses are common and response to treatment is poor in some cats.
  • Approximately 25% of cats experience side effects, especially lethargy, loss of appetite, or vomiting.
  • Serious complications are rare but include facial pruritis, liver failure, and adverse effects on the bone marrow.
  • Continual monitoring and blood tests at 3- to 6-month intervals are necessary during long-term treatment.
  • The disease is not cured; the thyroid tumor continues to grow in size and may metastasize.